Fraguas D, Díaz-Caneja CM, Pina-Camacho L, et al. - Researchers used a meta-analytic approach to evaluate the effectiveness of particular dietary interventions on symptoms, functions, and clinical domains in individuals with autism spectrum disorder (ASD). They analyzed 27 double-blind, randomized clinical trials, with 1,028 patients with ASD. These studies were identified from Ovid Medline, PsycINFO, Embase databases. They subsumed outcome variables under 4 clinical domains and 17 symptoms and/or functions groups. Among the examined individuals, 542 and 486 were in the intervention arms and in the placebo arms, respectively. Participant-weighted average age and participant-weighted average intervention duration were 7.1 years and 10.6 weeks, respectively. Compared with placebo, more efficacy of dietary supplementation (including omega-3, vitamin supplementation, and/or other supplementation), omega-3 supplementation, and vitamin supplementation was reported in improving several symptoms, functions, and clinical domains. Nonspecific dietary interventions were not supported as a management option for ASD but some specific dietary interventions may have a potential role in the treatment of some symptoms, functions, and clinical domains in ASD cases.