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Dietary intake on days with and without hypoglycemia in youth with type 1 diabetes: The Flexible Lifestyle Empowering Change trial

Pediatric Diabetes Oct 01, 2020

Igudesman D, Crandell J, Zhong VW, et al. - Researchers analysed calorie and carbohydrate consumption on days with and without hypoglycemia among adolescents with type 1 diabetes (T1D) to resolve a common belief that hypoglycemia is correlated with increased dietary intake. In the Flexible Lifestyle Empowering Change trial (age 13‐16 years, diabetes duration >1 year, hemoglobin A1c 8‐13%), days (N = 274) with 24‐hour dietary recalls and continuous glucose monitoring were available for 122 adolescents with T1D. Days without hypoglycemia, clinical hypoglycemia (54‐69 mg/dL) or clinically serious hypoglycemia (< 54 mg/dL) were further split into night‐ (12‐5:59 a.m.) and day (6 a.m.–11:59 p.m.). Data reported that 59%, 23% and 18% of days had no hypoglycemia, clinical hypoglycemia and clinically serious hypoglycemia, respectively. The daily intake of calories and carbohydrates among adolescents with T1D did not vary on days with and without hypoglycemia. Hypoglycemic episodes may be triggered by undereating with respect to the dose of insulin, accompanied by overeating, resulting in a net neutral difference. Larger studies should be designed to prospectively test the hypoglycemia‐diet relationship, considering the post‐hoc nature of these analyses.

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