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Dietary intake and biomarkers of folate and cobalamin status in Norwegian preschool children: The FINS-KIDS Study

The Journal of Nutrition Apr 30, 2020

Solvik BS, Strand TA, Kvestad I, et al. - Utilizing unadjusted and multiple linear regression models, researchers evaluated biomarkers of folate and vitamin B-12 status and explored their dietary determinants in healthy Norwegian children. The plasma concentrations of folate, cobalamin, total plasma homocysteine (tHcy), and methylmalonic acid were measured using baseline data obtained from a randomized controlled trial on the effect of fish intake on neurodevelopment in children aged 4 to 6 years. They used food-frequency questionnaires to evaluate dietary intake. Data reported that the median (IQR) of plasma folate (n = 197) and plasma cobalamin (n = 195) concentrations, respectively, were 15.2 (12.2–21.1) nmol/L and 785 (632–905) pmol/L. Red meat intake for dinner more than twice a week was related to 23% lower plasma folate. No other significant connections were noted between dietary intake and the biomarkers. There was adequate vitamin B-12 status among Norwegian preschool children from this cohort. Poor folate status was common, and was linked to high tHcy. During childhood, the implications of poor folate status should be a priority research issue.

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