Park JY, et al. - Researchers used the standardised folate database across 10 European countries, to determine the link between dietary folate intake and pancreatic cancer (PC) risk in 477,206 participants followed up for 11 years. A total of 865 incident primary PC cases were reported during follow-up. Using the residual method, energy-adjusted folate intake was practiced. They used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). They found no significant link between dietary folate intake and PC risk in multivariable analyses stratified by age, sex, study centre and adjusted for energy intake, smoking status, BMI, educational level, diabetes status, supplement use and dietary fibre intake: the HR of PC risk was 0.81 (95% CI: 0.51, 1.31; p_trend = 0.38) for those in the highest quartile of folate intake (≥353 μg/day) vs the lowest (<241 μg/day). They observed a positive trend in PC risk across folate quartiles [HR = 4.42 (95% CI: 1.05, 18.62) for ≥353 μg/day vs <241 μg/day, p_trend = 0.01] in current smokers. Nonetheless, no significant interaction was observed between smoking and dietary folate intake (p_interaction = 0.99).