Harris HR, Eliassen AH, Doody DR, et al. - In this prospective cohort study, researchers examined the correlation of dietary fat intake with the risk of uterine fibroids. In addition, they evaluated the association between erythrocyte membrane fatty acid (FA) levels and fibroid risk. During an 18-year period (1991-2009), they identified diagnosis of a total of 8,142 cases of fibroids defined on the basis of self-reported ultrasound or hysterectomy confirmation. In the multivariable models, intake of any dietary fats and fibroids showed no associations. However, on examining erythrocyte FAs, there appeared an inverse association between total n-3 polyunsaturated FAs and likelihood of fibroids. Further, an association appeared between total trans FAs and more odds of fibroids. Preliminary evidence gained suggests a possible role of n-3 polyunsaturated FAs and trans FAs in fibroid etiology.