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Dietary factors and mucosal immune response in celiac disease patients having persistent symptoms despite a gluten-free diet

Journal of Clinical Gastroenterology Apr 11, 2019

Laurikka P, et al. - Investigators examined the clinical and serological data as well as the mucosal recovery in 22 asymptomatic and 25 symptomatic celiac cases to estimate the importance of dietary factors, different small-bowel mucosal immune cell types, and epithelial integrity in the perpetuation of gastrointestinal symptoms in treated celiac disease cases. They kept the candidates (with negative celiac autoantibodies and recovered mucosal morphology) on a strict gluten-free diet (GFD). Higher mean fiber intake (20.2 vs 15.2 g/d) and density of CD3+ intraepithelial lymphocytes (IELs) (59.3 vs 45.0 cell/mm) were recorded in asymptomatic patients as compared to those with persistent symptoms. They observed similar but nonsignificant trend in γδ+ IELs (17.9 vs 13.5). They suggested predisposition of persistent symptoms in celiac disease due to low fiber intake.
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