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Dietary advanced glycation end-products and mortality after breast cancer in the Women's Health Initiative

Cancer Epidemiology, Biomarkers & Prevention Oct 27, 2021

Omofuma OO, Peterson LL, Turner DP, et al. - In postmenopausal women suffering from breast cancer, higher consumption of advanced glycation end-products (AGE) was identified to be related to higher risk of major causes of mortality.

  • A study of 2,023 postmenopausal women (aged 50 to 79 years) from Women's Health Initiative with first primary invasive breast cancer who completed a food frequency questionnaire post-diagnosis.

  • Adjusted hazard ratios (HR) were calculated for the link between tertiles of postdiagnosis N ε -carboxymethyl-lysine (CML)-AGE intake and death risk from all causes, breast cancer, and cardiovascular disease.

  • Post-follow-up (a median 15.1 years), there were 630 deaths due to all causes (193 were breast cancer–related, and 129 were cardiovascular disease–related).

  • CML-AGE intake after diagnosis was related to all-cause (HR T3vsT1 , 1.37), breast cancer (HR T3vsT1 , 1.49), and cardiovascular disease (HR T3vsT1 , 1.91) mortality.

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