Verhoeven F, et al. - This study assessed the impact of celecoxib [cyclooxygenase (COX)-2 selective inhibitor] and diclofenac (non selective COX inhibitor) on endothelial function and identified the underlying mechanisms in adjuvant-induced arthritis (AIA). According to findings, non-steroidal anti-inflammatory drugs' (NSAIDs) impact on endothelial function could not be extrapolated from their influence on arthritis severity. Furthermore, data indicated that for predicting cardiovascular (CV) risk of NSAIDs in rheumatoid arthritis (RA), alterations in blood pressure and plasma ADMA levels may not be useful.