Dichorionic twin-specific vs singleton growth references for diagnosis of fetal growth restriction
American Journal of Obstetrics and Gynecology Mar 26, 2021
Shea SK, Likins BJ, Boan AD, et al. - Researchers conducted a retrospective cohort study of dichorionic twin gestations ≥ 32 weeks with data available concerning serial growth ultrasounds and neonatal outcomes for analysis in order to compare a twin-specific growth reference (NICHD) and a singleton growth reference (Hadlock) for their utility in detecting fetal growth restriction (FGR) linked with adverse neonatal outcomes in dichorionic twin gestations. They included a total of 1,460 dichorionic twin infants with 8.1% (n = 118) FGR by both NICHD and Hadlock references, 8.8% (n = 129) FGR by Hadlock reference only, and 83.1% (n = 1213) with no FGR by either reference. Findings suggest superior performance of the NICHD twin-specific growth reference in differentiating the risk of adverse neonatal outcomes in dichorionic twin gestations diagnosed with FGR. Use of the Hadlock singleton growth reference more than doubles the number of dichorionic twins recognized as FGR who seem to be at low risk for neonatal morbidity, leading to unnecessary maternal anxiety, elevated antenatal testing, and possible iatrogenic preterm delivery.
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