Lip S, et al. - Given that diastolic blood pressure (DBP) lowering in hypertensive patients may potentially lead to increased cardiovascular risk, and therefore, researchers examined the link between blood pressure during the first 5 years of therapy and cause-specific hospital admissions or mortality in 10,355 hypertensive patients visiting the Glasgow Blood Pressure Clinic. For this purpose, they used 30-year follow-up data and multivariable adjusted Cox proportional hazard models. A composite of cardiovascular admissions and deaths was considered as the primary outcome. A U-shaped link (nadir, 92 mm Hg) for the primary cardiovascular outcome hazard and a reverse J-shaped link with all-cause death (nadir, 86 mm Hg) and noncardiovascular death (nadir, 92 mm Hg) was demonstrated by DBP. Overall, unintended outcomes of higher healthcare utilization due to increased cardiovascular morbidity may be seen in correlation with intensive blood pressure reduction. Increased risk of noncardiovascular mortality was observed in relation to low on-treatment DBP.