Lin Q, et al. - Given that intraocular metastasis (IOM) often negatively influences the quality of life in lung cancer and indicates a poor prognosis, researchers determined clinical differences between lung cancer cases with IOM and non-IOM (NIOM). This study included lung cancer patients (n=1608) who had metastasis to at least one site. Higher levels of alpha-fetoprotein, carcinoembryonic antigen, cancer antigen (CA)-125, CA-153, cytokeratin fragment 19 (CYFRA 21-1), and total prostate-specific antigen were found in the IOM group vs the NIOM group. For CA-153 and CYFRA 21-1, 22.2 U/mL and 6.785 ng/mL, respectively, were defined as cutoff values. In patients with metastatic lung cancer, both CA-153 and CYFRA 21-1 were identified as independent risk factors for IOM. In these patients, the most valuable was the combination of CA-153 and CYFRA 21-1 evaluation as far as detection of IOM was concerned.