Solnes LB, et al. – This study was designed to elucidate the role of neuroimaging in the setting of autoimmune encephalitides, comparing the utility of 18F–FDG PET/CT versus conventional brain imaging with MRI. The obtained data indicate that brain 18F–FDG PET/CT may play a significant role in the initial evaluation of patients with clinically suspected antibody–mediated autoimmune encephalitis. Moreover, given that it is more often abnormal when compared with MRI in the acute setting, this molecular imaging technique may be better positioned as an early biomarker of disease so that treatment may be initiated earlier, resulting in enhanced patient outcomes.