Ahn HS, Youn I, Na DG, et al. - In the present study, the researchers sought to compare the diagnostic performance of core‐needle biopsy (CNB) to fine‐needle aspiration (FNA) as a first‐line diagnostic tool in initially detected thyroid nodules, according to ultrasound (US) patterns. They involved 778 consecutive nodules from 705 patients who underwent CNB from one institution and 627 nodules from 583 patients who underwent FNA from two institutions. A 1:1 matching of 469 patients resulted in no significant differences between CNB and FNA for any covariates. According to results, CNB had a slightly higher rate of minor complication than FNA. The study indicates that CNB, when conducted by an experienced operator, has a complementary function as an alternative first-line diagnostic tool to FNA for the initial diagnosis of thyroid nodules.