Khoueir Z, et al. – The goal of the study described in this paper was to ascertain the diagnostic capability of peripapillary 3–dimensional (3D) retinal nerve fiber layer (RNFL) volume measurements from spectral domain optical coherence tomography (OCT) volume scans for open angle glaucoma (OAG). Peripapillary 3D RNFL volume demonstrated excellent diagnostic performance for detecting glaucoma. Peripapillary 3D RNFL volume parameters have the same or better diagnostic capability compared to peripapillary 2D RNFL thickness measurements, although differences were not statistically important.