Almond LM, et al. - Researchers reviewed data on patients with suspected retroperitoneal sarcoma (RPS) who underwent percutaneous biopsy followed by surgical resection 2005-2016 at one of two tertiary European sarcoma units in order to verify the diagnostic accuracy of percutaneous core biopsy with respect to histological diagnosis and tumor grade. They correlated histological tumor type and tumor grade on biopsy with postoperative histology among a total of 239 patients who underwent percutaneous core biopsy followed by surgical resection in Milan (163) or Birmingham (76). They observed variation in diagnostic accuracy with histological diagnosis, but with an overall concordance with final pathology following resection in 67.2% of biopsies. Findings supported the high reliability of a diagnosis of DDLPS or leiomyosarcoma on percutaneous biopsy. Possible identification of high-grade sarcomas with high specificity may allow for a study on neoadjuvant therapy in these patients.