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Diagnostic accuracy of noninvasive markers of steatosis, NASH, and liver fibrosis in HIV-monoinfected individuals at risk of nonalcoholic fatty liver disease (NAFLD): Results from the ECHAM study

Journal of Acquired Immune Deficiency Syndromes Mar 01, 2019

Lemoine M, et al. - Given a high risk of nonalcoholic fatty liver disease among HIV-monoinfected individuals, researchers estimated the accuracy of noninvasive methods for steatosis, nonalcoholic steatohepatitis (NASH), and fibrosis diagnosis, such as magnetic resonance imaging proton-density-fat-fraction (MRI-PDFF), FibroScan/controlled attenuation parameter (CAP), and biochemical tests, using liver biopsy as a reference. Antiretroviral therapy-controlled participants with persistently elevated transaminases and/or metabolic syndrome and/or lipodystrophy were analyzed. Findings support a high accuracy of MRI-PDFF and FibroScan/CAP for the diagnosis of steatosis in these patients. For the detection of NASH and fibrosis, they recommend considering the alanine aminotransferase level and APRI.

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