Reijnen C, et al. - Researchers assessed preoperative clinical biomarkers for their diagnostic accuracy for predicting lymph node metastasis (LNM) in endometrial cancer. They analyzed relevant studies identified from MEDLINE and EMBASE, with a focus on biomarkers based on recommended guidelines (cancer antigen 125 [Ca-125], lymphadenopathy on magnetic resonance imaging, computed tomography, and ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography or obtained by physical assessment (body mass index, cervical cytology, blood cell counts). This analysis included 83 studies with 18,205 patients. A large and moderate influence of Ca-125, thrombocytosis, and imaging on risk of LNM was shown in this study. Preoperative risk stratification could be improved by Ca-125, thrombocytosis, and imaging.