Leutner M, Matzhold C, Bellach L, et al. - Medical claims data of all Austrians from 2006 to 2007 was utilized to recognized all individuals treated with statins to compute their daily defined dose averages of six various types of statins in order to examine the association of various kinds and dosages of statins with osteoporosis, hypothesizing that the inhibition of the synthesis of cholesterol could impact sex-hormones, and hence, the diagnosis of osteoporosis. In conclusion, our results exhibit that in statin-treated individuals, the diagnosis of osteoporosis is dose-dependent. Hence, in low-dose and high-dose statin treatment, osteoporosis is underrepresented and overrepresented, respectively, showing the significance of prospective studies’ taking dose-dependency into consideration when examining the association between statins and osteoporosis.