Reinert CP, et al. - Researchers evaluated 70 subjects with malignant hematological diseases between December 2010 and March 2018 to examine if the spleen-to-liver-attenuation ratio on portal-venous enhancement phase CT images could recognize diffuse splenic infiltration in subjects with lymphoma. They compared the splenic volume, splenic attenuation, spleen-to-liver, spleen-to-aorta and spleen-to-musculature ratios on portal-venous phase CECT images, pre- to post-treatment and between the different lymphoma entities and observed lower spleen attenuation before treatment and spleen-to-liver attenuation ratio inclination after treatment. The spleen volume significantly decreased after successful treatment from 586.14.87 cm³ to 284.90 cm³. They also concluded an inverse correlation between spleen-to-liver attenuation ratio and FDG-uptake in cases working perfectly in normal-sized diffusely involved spleens.