Coulette S, et al. - From January 2011 to December 2017, nine consecutive patients with Susac syndrome and 73 patients with multiple sclerosis or clinically isolated syndrome (control group) were recruited in the study by the experts in order to evaluate its prevalence and importance of leptomeningeal enhancement in Susac syndrome using 3T postcontrast fluid-attenuated inversion recovery MR imaging. Subjects with Susac syndrome were markedly more inclined to manifest with leptomeningeal enhancement (5/9 vs 6/73 in the control group). Also, they had a markedly greaterleptomeningeal enhancement burden with ≥3 lesions. Regions of leptomeningeal enhancement were markedly more expected to be positioned in the posterior fossa. Interobserver agreement for leptomeningeal enhancement was observed to be good. A meaningful correlation among clinical relapses and an increase of both leptomeningeal enhancement and parenchymal lesion load was ascertained. Hence, leptomeningeal enhancement was observed to happen frequently in Susac syndrome and could be important for diagnosis and in prognosticating clinical relapse.