Tönnies T, et al. - In this population-based cross-sectional study, researchers examined whether diabetic nephropathy (DN) in young people with long-term type 1 diabetes is correlated with lower quality of life (QOL) and whether associations differ by the duration of diabetes. Overall, between 2009 and 2016, 1,462 youth between 11 and 17 years of age with diabetes onset between 0 and 4 years of age and a minimum of 10 years of diabetes completed QOL questionnaires. In youths with type 1 diabetes, the long-term microvascular complications can already impair chronic generic QOL. Differences in QOL appear to increase with the duration of diabetes between patients with and without DN.