Sanz-París A, et al. - Utilizing different electronic databases from the index date to December 2018, a systematic review and meta-analysis were performed by a literature search to contrast the metabolic benefits of diabetes-specific formulas (DSF) high in monounsaturated fatty acids (MUFA) with standard formulas (STDF) in adult individuals with type 1, type 2 diabetes or stress-induced hyperglycaemia. Randomised controlled trials that evaluated the health benefits of high a MUFA DSF STDF were involved. Of the 385 references analyzed, 18 studies involving 845 adults met the criteria for inclusion and contributed to the meta-analysis. Use of high a MUFA DSF contrasted with a STDF was related to a statistically significant reduction in postprandial glucose peak, incremental glucose response, area under the curve of plasma insulin, mean blood glucose level, glycosylated haemoglobin change, glucose variability, mean administered insulin dose, mean blood triglycerides and increase of mean blood high-density lipoproteins. Among patients with diabetes or stress-induced hyperglycaemia compared with a STDF, a DSF (oral supplements and tube feeds) high in MUFAs can improve glucose control and metabolic risk factors.