Shyu YC, et al. - Researchers sought to determine the correlation of DM with the development of hepa-tocellular carcinoma (HCC) with chronic hepatitis B virus infection (CHB) and affected the all-cause mortality. From the Longitudinal Cohort of Diabetes Patients database, they retrieved a total of 2966 CHB patients newly diagnosed with DM in 2000. Using propensity scores matching based on age, sex-gender, alcohol-related liver disease, and baseline liver cirrhosis, they compared the retrieved patients with the non-DM patients from the Taiwanese National Health Insurance Research Database. Outcomes revealed increasing disease development of HCC, HCC-related mortality and all-cause mortality in CHB patients in independent correlation to DM. Findings thereby emphasize adopting a clinical strategy for strict DM control for decreasing the risk of disease development in CHB patients.