Shyu YC, et al. - Researchers investigated the association of diabetes mellitus (DM) with the development of hepatocellular carcinoma (HCC) with chronic hepatitis B (CHB) and if it has any impact on all-cause mortality. From the Longitudinal Cohort of Diabetes Patients database, they retrieved a total of 2,966 CHB patients newly diagnosed with DM in 2000. Findings revealed significantly increased (3.3%) risk for HCC development and significantly increased (2.8%) risk of HCC-related mortality among CHB patients with DM vs non-DM. The DM cohort showed significantly higher all-cause mortality vs non-DM cohort. Findings thus suggest an independent association of DM with increasing disease development of HCC, HCC-related mortality, and all-cause mortality in CHB patients. Hence this study emphasizes strict DM control in order to reduce the risk of disease development in CHB patients.