Motta C, Assogna M, Bonomi CG, et al. - This study was carried out to assess if the APOE genotype interacts with tau protein and glucose metabolism dysfunctions to affect the pathological process. Researchers conducted a retrospective observational study including a total of 1,350 patients who had undergone a complete clinical investigation, neuropsychological assessment, lumbar puncture for CSF biomarkers analysis, and APOE genotyping. They enrolled 607 patients who fulfilled the clinical criteria of mild cognitive impairment or early dementia. The results reveal a clear dependency of CSF t-Tau levels on diabetes for APOE E4+ Alzheimer’s disease (AD) patients, implying important differences between APOE E4 related and non-related disease, with key implications for AD pathophysiology and treatment.