Li S, Chen D, Xiu M, et al. - In this case-control study involving 472 inpatients with chronic schizophrenia (SCZ) [54 T2DM and 418 non-T2DM] and 225 healthy controls, researchers looked at whether and how changes in serum BDNF levels were correlated with cognitive impairment in SCZ patients comorbid with T2DM. Serum BDNF levels and routine biochemical parameters have been measured. Findings revealed that there were substantially higher serum BDNF levels in SCZ patients with T2DM than in SCZ patients without T2DM. In delayed memory, SCZ patients with T2DM scored higher than SCZ patients without T2DM and still displayed significance after controlling for confounders. Increased levels of BDNF and improved cognitive performance, particularly delayed memory, may be linked to the pathophysiological process of T2DM in patients with chronic SCZ.