Takahara M, Iida O, Kohsaka S, et al. - Utilizing data from the 2012-2017 nationwide procedural databases of endovascular therapy (EVT) and percutaneous coronary intervention (PCI) in Japan (J-EVT and J-PCI), researchers performed a direct comparison of the clinical profile between patients undergoing EVT for lower-extremity peripheral artery disease (LE-PAD) vs those receiving PCI. This study involved 1,121,359 cases, including 103,887 EVT cases for critical limb ischemia or intermittent claudication and 1,017,472 PCI cases for acute coronary syndrome or stable angina. Compared with coronary artery disease (CAD) patients, LE-PAD patients demonstrated 1.96- and 6.39-times higher prevalence of diabetes mellitus and end-stage renal disease, respectively, which was noted regardless of age group. The two diseases differed in terms of exposure to other cardiovascular risk factors and the probability of cardiovascular risk clustering. Overall, no alike but rather considerably different patient profiles were confirmed between cases with clinically significant LE-PAD and CAD warranting revascularization.