Tinker SC, et al. - Researchers examined the association of pregestational and gestational diabetes with birth defects, adjusting for maternal age, race/ethnicity, body mass index, and study site, using data from the National Birth Defects Prevention Study, a multisite population-based case-control study that collected data on pregnancies ending in 1997-2011. Among case mothers and among control mothers, the estimated prevalence of pregestational diabetes was 2.6% and 0.7%, respectively; gestational diabetes prevalence was 5.5% and 4.7%, respectively. Pregestational diabetes was found to be statistically significantly related to 37 of the 41 birth defects evaluated, ranging from an adjusted odds ratio (aOR) of 86.0 for sacral agenesis to 2.6 for transverse limb deficiency. According to findings, many fewer defects were related to gestational diabetes (12/46) and those that were demonstrated much weaker links; the strongest was for cloacal exstrophy.