Mayr NP, et al. - In this retrospective analysis of a cohort of patients sedated with either dexmedetomidine (DEX) or a combination of propofol-opioid (PO) for transfemoral transcatheter aortic valve implantation (tf-TAVI), from a prospectively maintained TAVI registry, researchers compared DEX with PO with respect to periprocedural gas exchange and hemodynamic support. The primary endpoint was periprocedural partial pressure of carbon dioxide (P_aCO₂). DEX was found to be related to lower P_aCO₂ values and reduced requirements for vasopressor support in sedated TAVI patients. These findings showed that it is promising as an alternative to PO for sedation during TAVI.