Singh TK, et al. - Researchers tested dexmedetomidine's efficacy in reducing incidence and severity of early postoperative catheter-related bladder discomfort (CRBD) in 110 voluntary kidney donors of ages 18–60 years, American Society of Anesthesiologists physical status I and II of either sex. They administered 20 ml normal saline (NS) intravenous (IV) infusion over 15 min in the control group, whereas the dexmedetomidine group received dexmedetomidine 1 μg/kg made in 20 ml NS as IV infusion over 15 min. Findings demonstrated that an attenuated incidence and severity of CRBD in early postoperative settings was achieved, without adverse effects, with dexmedetomidine 1 μg/kg administered IV to patients 30 min before extubation.