Kruger BD, et al. - This study was performed to present a case series of cardiovascular intensive care unit patients with hyperthermia during dexmedetomidine administration, suggestive of drug fever. Supporting the published case reports, this case series indicates that use of dexmedetomidine may be related to the occurrence of clinically relevant hyperthermia. To gain certainty regarding the underlying mechanisms and risk factors, further explorations need to be carried out.