Cheatle MD, et al. - Researchers performed this study evaluating the discriminant predictive validity of the opioid risk tool (ORT) in a unique cohort of patients with chronic nonmalignant pain (CNMP) on long-term opioid therapy (LTOT) that displayed no evidence of developing an opioid use disorder (OUD) and a sample of patients with chronic nonmalignant pain (CNMP) that developed an OUD after commencing opioid therapy. As per results, patients with and without OUDs could be discriminated using the original ORT. Eliminating the gender-specific history of preadolescent sexual abuse item, a revised unweighted ORT (ORT-OUD) was developed that was notably superior in predicting the development of OUD in patients with CNMP on LTOT with high specificity, sensitivity, positive and negative predictive values. The ORT-OUD is identified to be the first tool that could predict the risk of developing an OUD in patients with CNMP receiving opioid therapy, as opposed to aberrant drug-related behaviors (ADRB) that can reflect a number of other issues. The ORT-OUD seems to be a simple, validated method that may assist in rapidly screening for the risk of developing OUD in patients on or being considered for opioid therapy.