Development of a new recurrence-free survival prediction nomogram for patients with primary non-muscle-invasive bladder cancer based on preoperative controlling nutritional status score
Cancer Management and Research Aug 19, 2021
Zhao L, Sun J, Wang K, et al. - This study’s findings demonstrate that for patients with non-muscle-invasive bladder cancer (NMIBC), the development of a new nomogram based on Controlling Nutritional Status (CONUT) score could increase the accuracy of recurrence prediction and improve individualized treatment plans.
Between January 2011 and December 2015, researchers retrospectively examined a total of 94 patients with NMIBC.
The univariate analysis showed that the age, history of smoking, pathological T stage, tumor grade, tumor size, and CONUT score were significantly associated with recurrence-free survival (RFS).
In this multivariate analysis, data demonstrated that CONUT score (HR =3.855, 95% CI 1.242– 11.970, p=0.020) was an independent predictor of RFS in patients with NMIBC.
A new age-, history of smoking-, pathologic factors- and the CONUT score-based scoring model was developed to predict recurrence of NMBIC, based on significant parameters in multivariate analysis and reliable recurrence predictors determined in predictive models and relevant guidelines.
Furthermore, they internally validated the nomogram using the consistency index and calibration plots, which indicated that the model has high prediction accuracy (c-index= 0.851).
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