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Development and validation of nomograms for predicting the prognosis of triple-negative breast cancer patients based on 379 Chinese patients

Cancer Management and Research Jan 08, 2020

Shi H, et al. - In order to provide nomograms that may be applied globally and include prognostic factors to foretell the prognosis of patients with triple-negative breast cancer (TNBC), researchers undertook this study wherein they retrospectively obtained and examined clinicopathological data of 379 patients with TNBC. They developed the nomogram of disease-free survival (DFS) by using four prognostic factors (albumin-to-globulin ratio, neutrophil-to-lymphocyte ratio, positive lymph nodes, and tumor size). Besides these factors, they took age into account in the development of the overall survival (OS) nomogram. Findings revealed a high accuracy of the nomograms as well as the superiority of the models in foretelling accuracy than the AJCC TNM staging system. Two web pages of the nomograms ie, DFS: sh-skipper.shinyapps.io/TNBC1/; OS: sh-skipper.shinyapps.io/TNBC2/, were also produced. The simplicity, as well as the easy application of these predictive models, especially of the web versions, was evident. Certain clinical utility of these in predicting the prognosis of patients with TNBC was also revealed. These not only can enable clinicians in recognizing patients at different prognostic risks but also reinforce the treatment or follow-up accordingly.
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