Development and validation of a risk score to identify children at risk of life-threatening asthma
Journal of Asthma Nov 06, 2020
Lee M, Bogdanova Y, Chan M, et al. - In the present study, the researchers developed and validated a prediction risk score for the identification of children at risk of developing life-threatening asthma (LTA). To develop and validate a risk score, the study used existing medical records and retrospective analysis. The sample consisted of children aged 2-17 years, admitted with a primary diagnosis of asthma, to Sydney Children’s Hospital between 2011-2016. A derivation and a validation cohort were randomly divided between children admitted to the intensive care unit with asthma at risk of LTA (cases) and those admitted into the general ward (comparison group). There were 1171 children in the study population; 586 in the derivation cohort and 585 in the validation cohort. For the development of a user-friendly risk score for early detection and monitoring of children at risk of developing LTA, a risk algorithm based on regularly collected clinical data may be used.
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