Stock SJ, Horne M, Bruijn M, et al. - Researchers developed and validated a risk prediction model using concentration of vaginal fluid fetal fibronectin (quantitative fFN), in combination with clinical risk factors, for the prediction of spontaneous preterm birth.

• Spontaneous preterm birth within 7 days of fFN testing was the primary outcome assessed.

• Data from 1,783 European women were used to develop and internally validate the model.

• External validation of the model was done in a prospective cohort study of 2,924 UK women.

• The analysis was performed including women with signs and symptoms of preterm labor between 22⁺⁰ to 34⁺⁶ weeks gestation.

• The prognostic model was identified as cost effective at a threshold of ≥ 2% risk of birth within 7 days of testing when compared with fFN alone.