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Development and validation of a prognostic model to predict the prognosis of patients who underwent chemotherapy and resection of pancreatic adenocarcinoma: A large international population-based cohort study

BMC Medicine Mar 29, 2019

Huang L, et al. - Researchers explored factors associated with survival in patients with resected TNM stage I–II pancreatic cancer (PaC) receiving chemotherapy and developing and validating a survival-predicting model internationally in this large international population-based study. A total of 11,837 resected PaC patients have been analyzed. Findings suggested an association of resection margin, hospital type, tumor size, positive and harvested lymph node number, lymph node ratio, and comorbidity number with survival in certain countries where the information was available. According to results, patients with resected PaC receiving chemotherapy have distinct characteristics independently linked to survival, with country-specific patterns and strengths. A robust survival - predicting model based on population benchmarks is established and validated internationally. The nomogram performs modestly like previous models predicting survival in resected PaC.
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