Perrot A, et al. - In a cohort of newly diagnosed patients with multiple myeloma (MM), experts assessed the prognostic effect of del(17p); t(4;14); del(1p32); 1q21 gain; and trisomies 3, 5, and 21. Via data attained from 1,635 patients in four trials, a higher prognostic index (PI) had a consistent correlation with a poor survival outcome every data set. Compared to patients in the low-risk category, hazard ratios were between six and 15 times higher for patients in the high-risk category for death, depending on the validation cohorts utilized. A worse survival was observed in patients with t(4;14) or del(17p) in the high-risk category vs those in the intermediate-risk category. A good performance was exhibited by the PI for distinguishing between patients who died and those who survived (Harrell’s concordance index greater than 70%). In the high-risk group, the cytogenetic PI enhanced the classification of newly diagnosed patients with MM vs recent classifications. Also, the development of risk-adapted treatment approaches was promoted by the results.