Avolio AW, Franco A, Schlegel A, et al. - In this multicenter cohort study, researchers developed and validated a simplified comprehensive model estimating at day 10 after liver transplant the early allograft failure (EAF) risk at day 90 (the Early Allograft Failure Simplified Estimation [EASE] score) and assessed how to identify early those patients with unsustainable EAF risk who are suitable for retransplant. The incidence of EAF on day 90 after transplant was 110 out of 1,609 patients (6.8%) in the derivation set and 41 out of 538 patients (7.6%) in the external validation set. The study found that EAF risk was reliably estimated by the developed EASE score. Model for End-stage Liver Disease score, transfused packed red blood cells, and hepatic vessel early thrombosis as well as transaminases, platelet, and bilirubin kinetics as variables on day 10 after transplant were all included in the score. Awareness of contributing issues will assist clinicians in managing risk factors and direct them through the difficult clinical decision to choose early liver retransplantation for patients. In translational research across transplant centers, the EASE score can be used.