Zhou C, et al. - A 7 immune-feature-based prognostic score (7IFBPS) for patients with oral squamous cell carcinoma (OSCC) following curative resection was developed and validated. From three independent cohorts, samples from 269 eligible patients were analyzed to characterize 14 immune features concerning detailed locations and densities of 7 types of tumor-infiltrating immune cells. Kaplan–Meier and validation Cox regression model were used in constructing 7IFBPS in training cohort. Verification was done in testing, validation and combined cohorts. Researchers noted significantly improved survival in correlation to high CD3 IM (invasive margin), CD3 CT (center of tumor), CD8 CT, CD45RO IM, CD45RO CT, FOXP3 IM and FOXP3 CT. Calculation of the 7IFBPS score was done employing the formula: 1.041 × CD3 IM + 1.24 × CD3 CT + 1.701 × CD8 CT + 1.127 × CD45RO IM + 1.348 × CD45RO CT + 1.089 × FOXP3 IM + 1.483 FOXP3 CT. All cohorts displayed improved survival in significant correlation to high 7IFBPS. Good agreement between prediction by 7IFBPS and actual observation was observed in calibration curves for survival probability. Findings demonstrate the value of 7IFBPS as a novel powerful prognostic classifier for resectable OSCC. Its incorporation into current prognostic regime may lead to better patient stratification.