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Determination of tuberculin skin test for isoniazid prophylaxis in BCG vaccinated children who are using anti‐TNF agents for rheumatologic diseases

Pediatric Pulmonology Jul 28, 2020

Kilinc AA, Onal P, Oztosun B, et al. - In the present study, the researchers sought to examine latent tuberculosis infection (LTBI) by the size of the tuberculin skin test (TST) and to determine the prevalence of tuberculosis (TB) in bacillus Calmette‐Guerin (BCG)‐vaccinated children undergoing anti-tumor necrosis factor (anti‐TNF) rheumatological disease treatment. Five hundred fifty-nine children [314 (56.3%) females and 245 (43.6%) males; mean age 13.1 ± 4.1 years] were included in the study. Demographics, anti‐TNF agents, TST size, and isoniazid prophylaxis has been recorded. In all patients, the mean TST size was 4.2 ± 4.7 mm. In BCG‐vaccinated children receiving anti‐TNF treatment, a TST size of ≥ 10 mm may differentiate children at high risk of LTBI reactivation.

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