Ramyashri S, Rao HL, Jonnadula GB, et al. - In this observational cross-sectional study, researchers sought to investigate the determinants of optical coherence tomography (OCT) parameters in a normal population from L V Prasad Eye Institute-Glaucoma Epidemiological and Molecular Genetic Study (LVPEI-GLEAMS). One thousand one hundred eyes (1,100 subjects) of normal adults aged 40 to 80 years from LVPEI-GLEAMS had macular and optic nerve head imaging with spectral-domain OCT (SD-OCT). OCT measurements have been significantly associated with age, gender, axial length, disc area and signal strength of the scan. When interpreting the OCT parameters in pathological conditions such as glaucoma, these variables may need to be addressed.