You S, et al. - In the main INTERACT (Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial)-2 randomized trial, researchers examined factors related to early and delayed neurological deterioration (END and DND, respectively) following acute spontaneous intracerebral hemorrhage. The study sample consisted of hypertensive intracerebral hemorrhage (<6 hours from symptom onset) patients with early intensive vs guideline-recommended blood pressure lowering. Of 2,598 attendees, 450 had either END or DND. Predictors of END were non-China recruitment, higher systolic blood pressure, larger baseline hematoma volume, left hemisphere hematoma location, intraventricular hemorrhage, subarachnoid extension, heterogeneous hematoma density, and cerebral white matter lesions. Predictors of DND were higher systolic blood pressure, lower diastolic blood pressure, higher glucose, larger baseline hematoma volume, intraventricular hemorrhage, lobar location, brain atrophy, and heterogeneous hematoma density. According to findings, END and DND and their influence on poor death and major disability outcomes are determined by common variables most directly related to the morphology of intracerebral hemorrhage and underlying cerebral characteristics.