Samakkarnthai P, Sfeir JG, Atkinson EJ, et al. - A cross-sectional observational study was conducted to ascertain if bone material strength index or cortical porosity (CtPo) is related to other diabetic complications. Researchers enrolled a sum of 171 T2DM patients (mean age, 68.8 years) and 108 age-matched nondiabetic controls (mean age, 67.3 years). They assessed bone material strength index applying micro indentation, skin advanced glycation end-products (AGEs) assessed using autofluorescence, high-resolution peripheral quantitative computed tomography at the distal radius and tibia, evaluation of diabetic microvascular complications including urine microalbuminuria, retinopathy, neuropathy, and vascular disease (ankle-brachial index and transcutaneous oxygen tension [TcPO2]). This study's findings illustrate that bone material properties are associated with AGE accumulation regardless of diabetes status, while CtPo in T2DM patients is correlated with TcPO2, a measure of microvascular blood flow.