Majid S, et al. - Through a retrospective study of 602 patients with primary invasive breast cancer, the researchers intended to recognize the clinicopathological determinants associated with non-sentinel node (SN) metastases and to discover the effect of the number of SN with macro-metastases and the type of SN metastases on metastatic involvement in non-SN. Two hundred and eleven and 391 patients had or did not metastases in non-SNs, respectively. A great risk of non-SNs metastases was noticed in the lobular type of breast cancer and multifocal tumors. In contrast to only micro-metastases, the presence of macro-metastases in SNs was related to a great risk of metastases to non-SNs. Regardless of the number of SNs removed surgically, the number of SN with macro-metastases elevated the risk of finding non-SNs with metastases. Hence, lobular cancer and multifocal tumors were concluded as correlated with a high risk of non-SN involvement. Also, the presence of the macro-metastases in SNs and the number of SN with macro-metastases had a definite association with the presence of metastases in non-SNs. However, no influence of the total number of surgically removed SNs on finding metastases in non-SNs could be ascertained. Further, these factors should be considered valuable in the decision of whether or not to omit completion axillary lymph node dissection.