Yunfei G, et al. - In a cohort of children with chronic tonsillitis (TC), the expression of glycogen synthase kinase 3β (GSK-3β) was evaluated by the researchers. They also assessed the association between GSK-3β activity index and inflammatory profiles of TC. Results demonstrated GSK-3β to be highly expressed in both TC and tonsillar hypertrophy groups but no significant difference was seen at mRNA and protein levels between groups. In the TC group, the GSK-3β activation index was seen to be positively associated with the levels of nuclear factor-κB (NF-κB), T-bet, and IFN-γ. For chronic recurrent inflammation in pediatric TC, GSK-3β activation index was noted to be a clinically applicable indicator.