Felix AS, et al. - Given transtubal spread may represent an important route of metastasis in endometrial cancer (EC), researchers assessed detection of intraluminal tumor cells (ILTCs) in relation to tumor characteristics and survival. Using logistic regression, they calculated odds ratios (ORs) and 95% confidence intervals (CIs) for links between demographic (age, race) and clinical [FIGO 2009 stage, lymphovascular space invasion (LVSI), histological subtype] characteristics and ILTCs. Using Cox regression, they computed hazard ratios (HRs) and 95% CIs for links between ILTCs and recurrence-free survival (RFS) and EC-specific survival, overall and stratified by histological subtype or stage. Findings showed an association of ILTCs with adverse EC prognostic features and reduced survival in cases of early stage or serous histology.