Scheer M, et al. - Researchers analyzed data of desmoplastic small round cell tumor (DSRCT) patients <40 years treated in prospective CWS trials 1997-2015 to determine optimal therapy for these patients and potential risk factors. They identified 60 patients with a median age of 14.5 years and male:female ratio of 4:1. Abdominal/retroperitoneal tumors were noted in 56/60 (93%). Potential risk factors comprised pleural effusions, venous thrombosis, and C-reactive protein (CRP) elevation. The best outcome was noted with the VAIA scheme (ifosfamide, vincristine, adriamycin, actinomycin D). Further investigated regarding maintenance therapy is required.