Dong Y, Li S, Sun X, et al. - Researchers investigated the candidate genes as well as the potential tumorigenesis discriminating between lung adenocarcinoma (LUAD) from lung squamous cell carcinoma (LUSC). Using the Gene Expression Omnibus database, two microarray datasets (GSE28571 and GSE10245) were downloaded and analyzed. As per findings, 47 differently expressed genes of the two datasets were ascertained. DSG3 (desmoglein 3) and KRT14 (keratin 14) were identified as potential biomarkers for differentiating between LUAD and LUSC. DSG3 or KRT14 suggested a worse prognosis in LUSC patients, which were identified to be related to pathways relevant to the TRAIL signaling pathway and TNF receptor signaling pathway as per bioinformatic analysis. Findings showed the potential of DSG3 and KRT14 to be employed as diagnostic markers, which presented here may facilitate improvements in differentiating between LUAD and LUSC in patients suffering from advanced non-small cell lung cancer.