Vásquez LM, Silva DL, Ramírez LF, et al. - Researchers undertook this retrospective, descriptive, observational study to characterize a group of patients exhibiting anaphylactic NSAID (nonsteroidal anti-inflammatory drug) cross-reactivity. Participants were patients who encountered anaphylaxis to one NSAID plus another acute reaction (anaphylactic or not) to at least one other NSAID of a different chemical group. This analysis involved 38 patients, including 28 (73.7%) women. The main organs impacted in the anaphylactic reaction were the skin and the respiratory system, happening in 35 (92.1%) and 33 (86.8%) patients, respectively. Presentation with cutaneous and respiratory involvement simultaneously was noted in 32 (84.3%) patients. Overall, findings demonstrated that women more frequently developed NSAID cross-anaphylaxis, and the main triggers were acetylsalicylic acid and dipyrone. The main allergic comorbidity was rhinitis and experts reported a high incidence of atopy. Selective COX-2 NSAIDs were tolerated by the majority.